3-Isopropylmalate dehydrogenase

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3-Isopropylmalate dehydrogenase
Identifiers
EC number 1.1.1.85
CAS number Template:CAS
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

3-Isopropylmalate dehydrogenase (EC 1.1.1.85) is an enzyme that catalyzes the chemical reactions[1][2][3][4]

(2R,3S)-3-isopropylmalate + NAD+ \rightleftharpoons 4-methyl-2-oxopentanoate + CO2 + NADH
(2R,3S)-3-isopropylmalate + NAD+ \rightleftharpoons (2S)-2-isopropyl-3-oxosuccinate + H+ + NADH
(2S)-2-isopropyl-3-oxosuccinate + H+ \rightleftharpoons 4-methyl-2-oxopentanoate + CO2

References

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