4,4'-Dimethylaminorex

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4,4'-DMAR
File:4,4'-Dimethylaminorex.svg
Systematic (IUPAC) name
4,5-Dihydro-4-methyl-5-(4-methylphenyl)-2-oxazolamine
Clinical data
Legal status
Identifiers
CAS Number 1445569-01-6 YesY
ATC code none
PubChem CID: 20741615
UNII 18Y239214S YesY
Chemical data
Formula C11H14N2O
Molecular mass 190.24 g/mol
  • CC(N=C(N)O1)C1C2=CC=C(C)C=C2
  • InChI=1S/C11H14N2O/c1-7-3-5-9(6-4-7)10-8(2)13-11(12)14-10/h3-6,8,10H,1-2H3,(H2,12,13)
  • Key:NPILLHMQNMXXTL-UHFFFAOYSA-N

4,4'-Dimethylaminorex (abbreviated as 4,4'-DMAR), sometimes referred to by the street name "Serotoni", is a psychostimulant and entactogen designer drug related to 4-methylaminorex and pemoline.[1] It was first detected in the Netherlands in December 2012,[2] and has been sold as a designer drug around Europe since mid-2013.

4,4'-DMAR had been linked to at least 31 deaths in Hungary, Poland and the UK by February 2014, mostly when consumed in combination with other drugs.[3] Nineteen deaths linked to 4,4'-DMAR were reported in Northern Ireland in the same time period.[4]

4,4'-DMAR acts as a potent and balanced serotonin-norepinephrine-dopamine releasing agent (SNDRA), with EC50 values for serotonin, norepinephrine, and dopamine release of 18.5 nM, 26.9 nM, and 8.6 nM, respectively.[1]

Legality

The UK Home Office expressed intent to ban 4,4'-DMAR following advice from the Advisory Council on the Misuse of Drugs[5] and subsequently it became a class A drug on 11 March 2015.[6]

4,4'-DMAR is an Anlage II controlled substance in Germany as of May 2015.[7]

Sweden's public health agency suggested to classify 4,4'-DMAR as hazardous substance on November 10, 2014.[8]

4,4'-DMAR is also banned in the Czech Republic.[9]

See also

References

  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ EMCDDA 2012 Annual report on the state of the drugs problem in Europe
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Unregulated stimulant drug blamed for 19 deaths, Belfast inquest told. The Guardian, Thursday 5 June 2014
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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