5-Carboxamidotryptamine

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5-Carboxamidotryptamine
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Systematic (IUPAC) name
3-(2-Aminoethyl)-1H-indole-5-carboxamide
Identifiers
CAS Number 74885-09-9
PubChem CID: 1809
IUPHAR/BPS 4
ChemSpider 1743 YesY
ChEBI CHEBI:48292 YesY
ChEMBL CHEMBL18840 YesY
Chemical data
Formula C11H13N3O
Molecular mass 203.240 g/mol
  • C1=CC2=C(C=C1C(=O)N)C(=CN2)CCN
  • InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) YesY
  • Key:WKZLNEWVIAGNAW-UHFFFAOYSA-N YesY
  (verify)

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.

5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity.[1][2][3] It has negligible affinity for the 5-HT1E and 5-HT1F receptors.[4] 5-CT binds strongest to the 5-HT1A receptor and it was once thought to be selective for this site.[5][6]

See also

References

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