5-Iodowillardiine

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5-Iodowillardiine
150px
Names
IUPAC name
(2S)-2-Amino-3-(5-iodo-2,4-dioxopyrimidin-1-yl)propanoic acid
Identifiers
140187-25-3 N
ChEMBL ChEMBL121915 YesY
ChemSpider 394358 YesY
DrugBank DB02818 YesY
4071
Jmol 3D model Interactive image
Interactive image
PubChem 447196
  • InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 YesY
    Key: AXXYLTBQIQBTES-BYPYZUCNSA-N YesY
  • InChI=1/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
    Key: AXXYLTBQIQBTES-BYPYZUCNBL
  • C1=C(C(=O)NC(=O)N1C[C@@H](C(=O)O)N)I
  • O=C(O)[C@@H](N)CN1/C=C(/I)C(=O)NC1=O
Properties
C7H8IN3O4
Molar mass 325.061 g/mol
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

5-Iodowillardiine is a selective agonist for the kainate receptor, with only limited effects at the AMPA receptor.[1] It is selective for kainate receptors composed of GluR5 subunits.[2][3] It is an excitotoxic neurotoxin in vivo,[4][5] but has proved highly useful for characterising the subtypes and function of the various kainate receptors in the brain and spinal cord.[6][7][8]

References

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  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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