AM-087

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
AM-087
AM-087.png
Systematic (IUPAC) name
(6aR,10aR)-3-(2-methyl-6-bromohex-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Identifiers
PubChem CID: 10717065
ChemSpider 8892405 YesY
ChEMBL CHEMBL199561 YesY
Chemical data
Formula C23H33BrO2
Molecular mass 421.410 g/mol
  • CC3(C)C1CC=C(C)CC1c2c(O)cc(C(C)(C)CCCCBr)cc2O3
  • InChI=1S/C23H33BrO2/c1-15-8-9-18-17(12-15)21-19(25)13-16(14-20(21)26-23(18,4)5)22(2,3)10-6-7-11-24/h8,13-14,17-18,25H,6-7,9-12H2,1-5H3/t17-,18-/m1/s1 YesY
  • Key:RJPGJHLVEUSRRA-QZTJIDSGSA-N YesY
  (verify)

AM-087 is an analgesic drug that is a cannabinoid agonist. It is a derivative of Δ8THC substituted on the 3-position side chain. AM-087 is a potent CB1 agonist with a Ki of 0.43nM, making it around 100x more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.[1][2][3]

See also

References

  1. ↑ Charalambous A, et al. Pharmacological evaluation of halogenated delta 8-THC analogs. Pharmacology, Biochemistry and Behaviour. 1991 Nov;40(3):509-12. PMID 1666915
  2. ↑ Nikas SP, et al. The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model. AAPS Journal. 2004 Oct 19;6(4):e30. PMID 15760095
  3. ↑ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X


<templatestyles src="Asbox/styles.css"></templatestyles>

Stub icon

This cannabinoid related article is a stub. You can help Wikipedia by expanding it.
Retrieved from "https://infogalactic.com/w/index.php?title=AM-087&oldid=3738372"