AM251

AM251

Systematic (IUPAC) name
1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl- N-(1-piperidyl)pyrazole-3-carboxamide
Identifiers
CAS Number	183232-66-8
PubChem	CID: 2125
IUPHAR/BPS	3317
ChemSpider	2040 Y
ChEBI	CHEBI:90724 Y
ChEMBL	CHEMBL285932 Y
Chemical data
Formula	C22H21Cl2IN4O
Molecular mass	555.238 g/mol
SMILES O=C(NN1CCCCC1)c4nn(c2ccc(Cl)cc2Cl)c(c3ccc(I)cc3)c4C
InChI InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) Y Key:BUZAJRPLUGXRAB-UHFFFAOYSA-N Y
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AM-251 is an inverse agonist at the CB₁ cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group. The resulting compound exhibits slightly better binding affinity for the CB₁ receptor (with a K_i value of 7.5nM) than SR141716A, which has a K_i value of 11.5nM, AM-251 is, however, about two-fold more selective for the CB₁ receptor when compared to SR141716A. Like SR141716A, it is additionally a μ-opioid receptor antagonist.

See also

• Discovery and development of Cannabinoid Receptor 1 Antagonists