CUGBP Elav-like family member 4

CUGBP, Elav-like family member 4
250px PDB rendering based on 2dgp.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DGP, 2DNK
Identifiers
Symbols	CELF4 ; BRUNOL-4; BRUNOL4
External IDs	OMIM: 612679 MGI: 1932407 HomoloGene: 23202 GeneCards: CELF4 Gene
Gene ontology Molecular function • nucleotide binding • translation repressor activity, nucleic acid binding • mRNA binding • BRE binding Cellular component • nucleus • cytoplasm Biological process • alternative mRNA splicing, via spliceosome • regulation of alternative mRNA splicing, via spliceosome • mRNA splice site selection • germ cell development • embryo development • negative regulation of translation • negative regulation of mRNA splicing, via spliceosome • positive regulation of mRNA splicing, via spliceosome • negative regulation of excitatory postsynaptic potential Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56853	108013
Ensembl	ENSG00000101489	ENSMUSG00000024268
UniProt	Q9BZC1	Q7TSY6
RefSeq (mRNA)	NM_001025087	NM_001146292
RefSeq (protein)	NP_001020258	NP_001139764
Location (UCSC)	Chr 18: 37.24 – 37.57 Mb	Chr 18: 25.48 – 25.75 Mb
PubMed search	[1]	[2]

CUGBP Elav-like family member 4 (CELF4) also known as bruno-like protein 4 (BRUNOL4) is a protein that in humans is encoded by the CELF4 gene.

Function

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.