Cloroqualone

Cloroqualone

Systematic (IUPAC) name
3-(2,6-Dichlorophenyl)-2-ethyl-4-quinazolinone
Clinical data
Pregnancy category	?
Routes of administration	?
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Biological half-life	?
Excretion	?
Identifiers
CAS Number	25509-07-3 N
ATC code	none
PubChem	CID: 63338
DrugBank	? N
ChemSpider	57005 Y
UNII	172D4Q6LOW Y
ChEMBL	CHEMBL2106114 N
Chemical data
Formula	C16H12Cl2N2O
Molecular mass	319.185
SMILES Clc3cccc(Cl)c3N/1C(=O)c2c(\N=C\1CC)cccc2
InChI InChI=1S/C16H12Cl2N2O/c1-2-14-19-13-9-4-3-6-10(13)16(21)20(14)15-11(17)7-5-8-12(15)18/h3-9H,2H2,1H3 Y Key:SONHVLIDLXLSOL-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Cloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative and antitussive properties resulting from its agonist activity at the β subtype of the GABA_a receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients as a cough medicine. Cloroqualone has weaker sedative properties than methaqualone and was sold for its useful cough-suppressing effects, but was withdrawn from the French market in 1994 because of concerns about its potential for abuse and overdose.

See also

• Methaqualone
• Afloqualone
• Etaqualone
• Methylmethaqualone
• Mecloqualone
• Mebroqualone
• Diproqualone
• Gamma-Aminobutyric acid