Cyclin-dependent kinase inhibitor protein

This article is about the cell cycle protein. For the medical therapy, see CDK inhibitor.

Cyclin-dependent kinase inhibitor
File:PDB 1jsu EBI.jpg Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Identifiers
Symbol	CDI
Pfam	PF02234
InterPro	IPR003175
SCOP	1jsu
SUPERFAMILY	1jsu
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase. Several function as tumor suppressor genes. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest at the G₁ phase.

Examples

Protein	Gene	Interacts with
p16	CDKN2A	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p15	CDKN2B	Cyclin-dependent kinase 4
p18	CDKN2C	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p19	CDKN2D	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p21 / WAF1	CDKN1A	Cyclin E1/Cyclin-dependent kinase 2
p27	CDKN1B	Cyclin D3/Cyclin-dependent kinase 4, Cyclin E1/Cyclin-dependent kinase 2
p57	CDKN1C	Cyclin E1/Cyclin-dependent kinase 2
	CDKN3	Cyclin-dependent kinase 2

External links

• Cyclin-Dependent Kinase Inhibitor Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)