Ditolylguanidine

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Ditolylguanidine
1,3-Ditolylguanidine.svg
Systematic (IUPAC) name
1,2-bis(2-methylphenyl)guanidine
Identifiers
CAS Number 97-39-2 YesY
ATC code none
PubChem CID: 7333
IUPHAR/BPS 6684
ChemSpider 7056 YesY
ChEMBL CHEMBL282433 YesY
Chemical data
Formula C15H17N3
Molecular mass 239.316 g/mol
  • N(=C(/Nc1ccccc1C)N)\c2ccccc2C
  • InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18) YesY
  • Key:OPNUROKCUBTKLF-UHFFFAOYSA-N YesY
  (verify)

Ditolylguanidine is a sigma receptor agonist.[1] It is selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity.[2] It has neuroprotective[3] and antidepressant effects,[4] and potentiates the effects of NMDA antagonists.[5]

See also

References

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  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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