XPB

Excision repair cross-complementation group 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4ERN
Identifiers
Symbols	ERCC3 ; BTF2; GTF2H; RAD25; TFIIH; TTD2; XPB
External IDs	OMIM: 133510 MGI: 95414 HomoloGene: 96 GeneCards: ERCC3 Gene
EC number	3.6.4.12
Gene ontology Molecular function • DNA binding • damaged DNA binding • ATP-dependent DNA helicase activity • protein kinase activity • protein binding • ATP binding • GTP binding • protein C-terminus binding • DNA-dependent ATPase activity • transcription factor binding • RNA polymerase II carboxy-terminal domain kinase activity • ATPase activity • dATP binding • peptide binding • 3'-5' DNA helicase activity • protein N-terminus binding Cellular component • core TFIIH complex • nucleus • nucleoplasm • holo TFIIH complex Biological process • nucleotide-excision repair, DNA duplex unwinding • nucleotide-excision repair, DNA damage removal • response to hypoxia • DNA topological change • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • protein phosphorylation • apoptotic process • response to oxidative stress • protein localization • response to UV • UV protection • gene expression • viral process • nucleotide-excision repair, DNA incision • hair cell differentiation • regulation of gene expression, epigenetic • positive regulation of apoptotic process • negative regulation of gene expression, epigenetic • positive regulation of transcription from RNA polymerase II promoter • positive regulation of viral transcription • regulation of mitotic cell cycle phase transition Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ERCC3 202176 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2071	13872
Ensembl	ENSG00000163161	ENSMUSG00000024382
UniProt	P19447	P49135
RefSeq (mRNA)	NM_000122	NM_133658
RefSeq (protein)	NP_000113	NP_598419
Location (UCSC)	Chr 2: 127.26 – 127.29 Mb	Chr 18: 32.24 – 32.27 Mb
PubMed search	[1]	[2]

XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

Structure

The 3D-structure of the archaeal homolog of XPB has been solved by X-ray crystallography by Dr. John Tainer and his group at The Scripps Research Institute.

Function

XPB plays a significant role in normal basal transcription, transcription coupled repair (TCR), and nucleotide excision repair (NER). Purified XPB has been shown to unwind DNA with 3’-5’ polarity.

Disorders

Mutations in XPB and other related complementation groups, XPA-XPG, leads to a number of genetic disorders such as Xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy.

Interactions

XPB has been shown to interact with:

• BCR gene,
• CDK7,
• ERCC2,
• GTF2H1,
• GTF2H2,
• GTF2H4,
• GTF2H5,
• P53,
• PSMC5, and
• XPC.

See also

• XP

External links

• GeneReviews/NIH/NCBI/UW entry on Xeroderma Pigmentosum
• XPBC-ERCC-3 protein at the US National Library of Medicine Medical Subject Headings (MeSH)