FGF1

This article is about fibroblast growth factor-1. For the internal ribosome entry site, see FGF-1 internal ribosome entry site (IRES).

Fibroblast growth factor 1 (acidic)
250px PDB rendering based on 1afc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1QCT, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2LDN, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4QO3
Identifiers
Symbols	FGF1 ; AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1
External IDs	OMIM: 131220 MGI: 95515 HomoloGene: 625 ChEMBL: 2120 GeneCards: FGF1 Gene
Gene ontology Molecular function • fibroblast growth factor receptor binding • protein binding • growth factor activity • heparin binding • S100 protein binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • nucleoplasm • cytosol • cell cortex Biological process • angiogenesis • organ induction • signal transduction • epidermal growth factor receptor signaling pathway • multicellular organismal development • positive regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • anatomical structure morphogenesis • lung development • positive regulation of cell migration • cellular response to heat • Fc-epsilon receptor signaling pathway • positive regulation of MAP kinase activity • innate immune response • positive regulation of cholesterol biosynthetic process • positive regulation of angiogenesis • positive regulation of transcription from RNA polymerase II promoter • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of epithelial cell proliferation • positive regulation of cell division • branch elongation involved in ureteric bud branching • positive regulation of ERK1 and ERK2 cascade • mesonephric epithelium development • positive regulation of intracellular signal transduction • regulation of endothelial cell chemotaxis to fibroblast growth factor Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FGF1 205117 at tn.png
File:PBB GE FGF1 208240 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2246	14164
Ensembl	ENSG00000113578	ENSMUSG00000036585
UniProt	P05230	P61148
RefSeq (mRNA)	NM_000800	NM_010197
RefSeq (protein)	NP_000791	NP_034327
Location (UCSC)	Chr 5: 142.59 – 142.7 Mb	Chr 18: 38.84 – 38.93 Mb
PubMed search	[1]	[2]

Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene.

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.

In mice with diet-induced diabetes, the equivalent of type 2 diabetes in humans, a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for > 2 days.

Interactions

FGF1 has been shown to interact with:

• CSNK2A2,
• CSNK2B,
• CSNK2A1,
• FIBP,
• FGFR1,
• FGFR2
• FGFR3,
• FGFR4,
• HSPA9, and
• S100A13.

See also

• Fibroblast growth factor