Lon protease family
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| ATP-dependent protease La (LON) domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:PDB 2ane EBI.jpg
crystal structure of n-terminal domain of e.coli lon protease
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| Identifiers | |||||||||
| Symbol | LON | ||||||||
| Pfam | PF02190 | ||||||||
| Pfam clan | CL0178 | ||||||||
| InterPro | IPR003111 | ||||||||
| SMART | LON | ||||||||
| MEROPS | S16 | ||||||||
| SCOP | 1zbo | ||||||||
| SUPERFAMILY | 1zbo | ||||||||
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| Lon protease (S16) C-terminal proteolytic domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LON | ||||||||
| Pfam | PF05362 | ||||||||
| Pfam clan | CL0329 | ||||||||
| InterPro | IPR008269 | ||||||||
| MEROPS | S16 | ||||||||
| SCOP | 1rr9 | ||||||||
| SUPERFAMILY | 1rr9 | ||||||||
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In molecular biology, the Lon protease family is a family of proteases. They are found in archaea, bacteria and eukaryotes. Lon proteases are ATP-dependent serine peptidases belonging to the MEROPS peptidase family S16 (lon protease family, clan SJ). In the eukaryotes the majority of the Lon proteases are located in the mitochondrial matrix.[1][2] In yeast, the Lon protease PIM1 is located in the mitochondrial matrix. It is required for mitochondrial function, it is constitutively expressed but is increased after thermal stress, suggesting that PIM1 may play a role in the heat shock response.[3]
See also
References
External links
This article incorporates text from the public domain Pfam and InterPro IPR003111
