Lymphotoxin alpha
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Lymphotoxin-alpha (LT-alpha) or Tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene.[1][2]
Function
Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.[3]
In LTα knockout mice, all Peyer's patches and lymph nodes will fail to develop indicating LTα's importance in immunological development.[4]
Interactions
Lymphotoxin alpha has been shown to interact with LTB.[5][6][7]
See also
References
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Further reading
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