Naphthylpiperazine

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Naphthylpiperazine
Skeletal formula of naphthylpiperazine
Ball-and-stick model of the naphthylpiperazine molecule
Systematic (IUPAC) name
1-(naphthalen-1-yl)piperazine
Clinical data
Legal status
  • Uncontrolled
Routes of
administration		 Oral
Identifiers
CAS Number 57536-86-4
ATC code none
PubChem CID: 1342
IUPHAR/BPS 3
ChemSpider 1302
Chemical data
Formula C14H16N2
Molecular mass 212.29 g/mol
  • c2cc(c1ccccc1c2)N3CCNCC3

1-(-1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors,[1][2][3] while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors.[4][5][6] It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors,[7][8][9][10] and may bind to 5-HT4 and the SERT as well.[11][12] In animals it produces effects including hyperphagia,[13][14][15] hyperactivity,[16][17] and anxiolysis,[17][18][19][20] of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor.

See also

References

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