PSB-SB-1202

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PSB-SB-1202
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Systematic (IUPAC) name
7-pentyl-5-methoxy-3-(2-methoxybenzyl)-2H-chromen-2-one
Identifiers
CAS Number 1399049-60-5
PubChem CID: 70677953
Chemical data
Formula C23H26O4
Molecular mass 366.45
  • O=C1C(CC2=C(OC)C=CC=C2)=CC3=C(C=C(CCCCC)C=C3OC)O1

PSB-SB-1202 is a coumarin derivative which is an agonist at the cannabinoid receptors CB1 and CB2, with a CB1 Ki of 32nM and a CB2 Ki of 49nM.[1] It is also a weak antagonist at the related receptor GPR55, with an IC50 of 6350nM, but has no significant affinity for GPR18.[2]

See also

References

  1. ↑ Rempel V, Volz N, Hinz S, Karcz T, Meliciani I, Nieger M, Wenzel W, Bräse S, Müller CE. 7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists. Journal of Medicinal Chemistry. 2012 Sep 27;55(18):7967-77. PMID 22916707
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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