Propyphenazone
From Infogalactic: the planetary knowledge core
Systematic (IUPAC) name | |
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1,5-Dimethyl-2-phenyl-4-propan-2-yl-pyrazol-3-one
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Clinical data | |
AHFS/Drugs.com | International Drug Names |
Routes of administration |
Oral |
Identifiers | |
CAS Number | 479-92-5 |
ATC code | N02BB04 (WHO) |
PubChem | CID: 3778 |
ChemSpider | 3646 |
UNII | OED8FV75PY |
ChEBI | CHEBI:135538 |
ChEMBL | CHEMBL28318 |
Chemical data | |
Formula | C14H18N2O |
Molecular mass | 230.306 g/mol |
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Propyphenazone is a derivative of phenazone[1] with similar analgesic and antipyretic effects.
Adverse effects of propyphenazone
There have been case reports describing risk of acute inferior myocardial infarction with low atrial rhythm due to propyphenazone (Kounis syndrome).[2][citation needed]
Countries that have banned propyphenazone
Excerpt from WHO comments:
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- “Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations.”[3]
- South Korea[4] - as reported by PharmAsia News in 2009:
- Malaysia[4]
- Thailand[4]
- Turkey - production and sale banned in January 1986 due to incidence of severe adverse reactions.[3]
- India- Still in use. Saridon tablets contain 150mg/tablet.
References
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Categories:
- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Drugs with no legal status
- Articles with unsourced statements from January 2013
- Analgesics
- Antipyretics
- Pyrazolones
- Analgesic stubs