RNF125

Ring finger protein 125, E3 ubiquitin protein ligase
Identifiers
Symbols	RNF125 ; TNORS; TRAC-1; TRAC1
External IDs	OMIM: 610432 HomoloGene: 32369 GeneCards: RNF125 Gene
Gene ontology Molecular function • zinc ion binding • ligase activity • ubiquitin conjugating enzyme binding • ubiquitin protein ligase activity Cellular component • intracellular Biological process • protein polyubiquitination • adaptive immune response • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of type I interferon production • innate immune response Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE RNF125 207735 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54941	n/a
Ensembl	ENSG00000101695	n/a
UniProt	Q96EQ8	n/a
RefSeq (mRNA)	NM_017831	n/a
RefSeq (protein)	NP_060301	n/a
Location (UCSC)	Chr 18: 32.02 – 32.07 Mb	n/a
PubMed search	[1]	n/a

E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene.

This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.