Sodium salicylate

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Sodium salicylate
Sodium salicylate2DCSD.svg
Names
IUPAC name
Sodium salicylate
Other names
Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Sodium 2-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
Identifiers
54-21-7 YesY
ChEMBL ChEMBL447868 YesY
ChemSpider 5689 YesY
DrugBank DB01398 YesY
EC Number 200-198-0
Jmol 3D model Interactive image
KEGG D00566 N
PubChem 16760658
RTECS number VO5075000
UNII WIQ1H85SYP YesY
  • InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1 YesY
    Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M YesY
  • InChI=1/C7H6O3.Na/c8-6-4-2-1- 3-5(6)7(9)10;/h1-4,8H,(H,9,10); /q;+1/p-1/fC7H5O3.Na/q-1;m
  • InChI=1/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
    Key: ABBQHOQBGMUPJH-REWHXWOFAO
  • [Na+].O=C([O-])c1ccccc1O
Properties
C7H5NaO3
Molar mass 160.10 g·mol−1
Appearance white crystals
Melting point 200 °C (392 °F; 473 K)
25.08 g/100 mL (-1.5 °C)
107.9 g/100 mL (15 °C)
124.6 g/100 mL (25 °C)
141.8 g/100 mL (78.5 °C)
179 g/100 g (114 °C)[1]
Solubility soluble in glycerol, 1,4-Dioxane, alcohol[1]
Solubility in methanol 26.28 g/100 g (15 °C)
34.73 g/100 g (67.2 °C)[1]
Pharmacology
ATC code N02BA04
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.[2]

Properties

Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.[citation needed]

Uses

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [3][4][5] and also necrosis.[6] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.[7]

References

  1. ↑ 1.0 1.1 1.2 http://chemister.ru/Database/properties-en.php?dbid=1&id=2993
  2. ↑ Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.

External links

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