Thymosin beta-4

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Thymosin beta 4, X-linked
Available structures
PDB Human UniProt search: PDBe, RCSB
Identifiers
Symbols TMSB4X ; FX; PTMB4; TB4X; TMSB4
External IDs OMIM: 300159 GeneCards: TMSB4X Gene
RNA expression pattern
File:PBB GE TMSB4X 216438 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7114 n/a
Ensembl ENSG00000205542 n/a
UniProt P62328 n/a
RefSeq (mRNA) NM_021109 n/a
RefSeq (protein) NP_066932 n/a
Location (UCSC) Chr X:
12.98 – 12.98 Mb		 n/a
PubMed search [1] n/a

Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene.[1][2][3]

The protein consists (in humans) of 43 amino acids (msdkpdmaei ekfdksklkk tetqeknplp sketieqekq ages) molWt 4921.[4]

Function

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See also: Biological activities of thymosin β4

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y (TMSB4Y).[3]

Clinical significance

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See also: Beta thymosins in tissue regeneration

It has been studied in a number of clinical trials.[5]

The thymosin beta-4 peptide, if used after a heart attack, might reactivate cardiac progenitor cells to repair damaged heart tissue.[6][7]

Doping in Sports

Thymosin beta-4 was allegedly used by some players in various Australian football codes and is under investigation by the Australian Sports Anti-Doping Authority for anti-doping violations [8][9]

Players of the Essendon Football Club were cleared of use of Thymosin Beta 4 on March 30, 2015 by the Australian Football League anti-doping tribunal, however after an appeal by the World Anti-Doping Agency, this was overturned on the January 12, 2016.[10]

Interactions

TMSB4X has been shown to interact with ACTA1[11][12] and ACTG1.[13][14]

See also

References

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Further reading

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