Thiocarlide
Structural formula of thiocarlide | |
Space-filling model of the thiocarlide molecule | |
Systematic (IUPAC) name | |
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1,3-bis[4-(3-methylbutoxy)phenyl]thiourea
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Identifiers | |
CAS Number | 910-86-1 |
ATC code | J04AD02 (WHO) |
PubChem | CID: 3001386 |
ChemSpider | 2272774 |
UNII | 43M23X81Y2 |
ChEMBL | CHEMBL214920 |
Chemical data | |
Formula | C23H32N2O2S |
Molecular mass | 400.578 g/mol |
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Thiocarlide (or tiocarlide or isoxyl) is a thiourea drug used in the treatment of tuberculosis, inhibiting synthesis of oleic acid and tuberculostearic acid.[1]
Thiocarlide has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis.[2] Isoxyl inhibits M. bovis with six hours of exposure, which is similar to isoniazid and ethionamide, two other prominent anti-TB drugs. Unlike these two drugs, however, isoxyl also partially inhibits the synthesis of fatty acids.
Thiocarlide was developed by a Belgian company, Continental Pharma S.A. Belgo-Canadienne in Brussels, Belgium. The head researcher was Professor N. P. Buu-Hoi, head of Continental Pharma's Research Division.
References
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