Totally drug-resistant tuberculosis
Totally drug-resistant tuberculosis (TDR-TB) is a generic term for tuberculosis strains that are resistant to a wider range of drugs than strains classified as extensively drug-resistant tuberculosis. TDR-TB has been identified in three countries; India, Iran, and Italy. The emergence of TDR-TB has been documented in four major publications.[1][2][3][4] However, it is not yet recognised by the World Health Organization.
TDR-TB has resulted from further mutations within the bacterial genome to confer resistance, beyond those seen in XDR- and MDR-TB. Development of resistance is associated with poor management of cases. Drug resistance testing occurs in only 9% of TB cases worldwide. Without testing to determine drug resistance profiles, MDR- or XDR-TB patients may develop resistance to additional drugs.[2] TDR-TB is relatively poorly documented, as many countries do not test patient samples against a broad enough range of drugs to diagnose such a comprehensive array of resistance. The United Nations' Special Programme for Research and Training in Tropical Diseases has set up a TDR Tuberculosis Specimen Bank to archive specimens of TDR-TB.[5]
See also
- Extensively drug-resistant tuberculosis (XDR-TB)
- Multi-drug-resistant tuberculosis (MDR-TB)
References
- ↑ Migliori GB, De Iaco G, Besozzi G, Centis R, Cirillo DM. First tuberculosis cases in Italy resistant to all tested drugs. Euro Surveill. 2007;12(20):pii=3194. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=3194
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External links
- MDRIpred : Designing inhibitors against drug tolerant M. Tuberculosis, Chemistry Central Journal 2013, 7:49
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