ΔP (Delta P) is a mathematical term used to illustrate a change (Δ) in pressure (P).
where ρ is the density of the fluid, the Darcy–Weisbach equation can also be written in terms of pressure loss:
In general, compliance is defined by the change in volume (ΔV) versus the associated change in pressure (ΔP), or ΔV/ΔP. During mechanical ventilation, compliance can be influenced by 3 key physiologic factors:
Lung compliance is influenced by a variety of primary abnormalities of lung parenchyma, both chronic and acute. Airway resistance is typically increased by bronchospasm and airway secretions. Chest wall compliance can be decreased by fixed abnormalities (e.g. kyphoscoliosis, morbid obesity) or more variable problems driven by patient agitation while intubated.
Dynamic Compliance (Cdyn)
where PIP = peak inspiratory pressure (the maximum pressure during inspiration), and PEEP = positive end expiratory pressure. Alterations in airway resistance, lung compliance and chest wall compliance influence Cdyn.
Static Compliance (Cstat)
where Pplat = plateau pressure. Pplat is measured at the end of inhalation and prior to exhalation using an inspiratory hold maneuver. During this maneuver, airflow is transiently (~0.5 sec) discontinued, which eliminates the effects of airway resistance. Pplat is never > PIP and is typically < 3-5 cmH2O lower than PIP when airway resistance is normal.
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