This article is about the year 1620. For the computer, see IBM 1620
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1620 (MDCXX) was a leap year starting on Wednesday (dominical letter ED) of the Gregorian calendar and a leap year starting on Saturday (dominical letter BA) of the Julian calendar, the 1620th year of the Common Era (CE) and Anno Domini (AD) designations, the 620th year of the 2nd millennium, the 20th year of the 17th century, and the 1st year of the 1620s decade. Note that the Julian day for 1620 is 10 calendar days difference, which continued to be used from 1582 until the complete conversion of the Gregorian calendar was entirely done in 1929.
- July 3 – Under the terms of the Treaty of Ulm, the Protestant Union declares neutrality and ceases to support Frederick V of Bohemia.
- July 15 – The ship Speedwell departs Delfshaven with the Leiden colonists and Pilgrims.
- August 5 (O.S.) – The Mayflower and Speedwell depart together from Plymouth, England, but the Speedwell starts to leak again and must stop.
- August 7
- August 8 – Mysterious rain of frogs in Weil der Stadt.
- September 6 (O.S.) – The Mayflower departs from Plymouth, England, on its 3rd attempt without the Speedwell, arriving on November 11 (Old Style date) at Cape Cod (named from Concord voyage of 1602).
- September 17–October 7 – Battle of Cecora: The Ottoman Empire defeats Polish–Lithuanian Commonwealth–Moldavian troops.
- October 6 – The Roman Catholic Ras Sela Kristos, half-brother of the Emperor Susenyos crushes a group of rebels in at Mount Amedamit in Gojjam, Ethiopia, who were opposed to Susenyos' pro-Catholic beliefs.
- November 3 – The Great Patent is granted to Plymouth Colony.
- November 8 – Thirty Years' War – Battle of White Mountain: Catholic forces are victorious in only two hours near Prague.
- November 21 (November 11 O.S.) – The Mayflower arrives inside the tip of Cape Cod at what becomes known as Provincetown Harbor, with the Pilgrims and Planters. 41 Plymouth Colony settlers sign the Mayflower Compact, the first governing document of the colony, onboard the ship.
- November 25 – Wedding of Gustav II Adolf and Maria Eleonora
- December 21 – Plymouth Colony: William Bradford and the Mayflower Pilgrims land on what becomes known as Plymouth Rock in Plymouth, Massachusetts.
- January 1
- January 5 – Miklós Zrínyi, Croatian military commander (d. 1664)
- January 9 – Anton Günther I, Count of Schwarzburg-Sondershausen (d. 1666)
- January 17 – Anton Janson, Dutch type founder and printer (d. 1687)
- January 31 – Prince Georg Friedrich of Waldeck, Dutch General and German Field Marshal (d. 1692)
- February 1 – Gustaf Bonde, Swedish politician (d. 1667)
- February 3 – Sir James Clavering, 1st Baronet, English landowner (d. 1702)
- February 4 – Gustaf Bonde, Swedish statesman (d. 1667)
- February 5 – Paul Barbette, Dutch physician (d. 1666)
- February 13 – Girolamo Casanata, Italian cardinal (d. 1700)
- February 15 – François Charpentier, French archaeologist and man of letters (d. 1702)
- February 16 – Frederick William, Elector of Brandenburg (d. 1688)
- February 23 – Francis Newport, 1st Earl of Bradford, English politician (d. 1708)
- March 10 – Johann Heinrich Hottinger, Swiss philologist and theologian (d. 1667)
- March 13 – Alexander Seton, 1st Viscount of Kingston (d. 1691)
- March 29 – Edward Digges, English barrister and colonist, Colonial Governor of Virginia (d. 1674)
- April 17 – Marguerite Bourgeoys, French Catholic nun, founder of the Congregation of Notre Dame (d. 1700)
- April 18 – Winston Churchill (1620–1688) (d. 1688)
- April 21 – Salvatore Castiglione, Italian painter (d. 1676)
- April 24 – John Graunt (d. 1674)
- May 3 – Bogusław Radziwiłł, Polish-Lithuanian noble (d. 1669)
- May 23 – Pieter Neefs the Younger, Flemish painter (d. 1675)
- May 25 – Warwick Mohun, 2nd Baron Mohun of Okehampton, Member of the English Parliament (d. 1665)
- June 6 – Sir John Covert, 1st Baronet, English politician (d. 1679)
- June 11 – John Moore (Lord Mayor), Member of Parliament for the City of London (d. 1702)
- July 8 – Zhang Huangyan (张煌言), Chinese writer，poet and military official of Ming dynasty(d. 1664)
- July 20
- July 21 – Jean Picard, French astronomer and priest (d. 1704)
- July 31 – Juan Ignacio de la Carrera Yturgoyen, Chilean politician (d. 1682)
- August 6 – William Hiseland (d. 1732)
- August 22 – Alexander Rigby (died 1694), English politician (d. 1694)
- August 24 – Thomas Stucley (MP), English politician (d. 1663)
- August 26 – Ernst Bogislaw von Croÿ (d. 1684)
- September 4 – Ernest Gottlieb, Prince of Anhalt-Plötzkau (d. 1654)
- September 6 – Isabella Leonarda, Italian composer (d. 1704)
- September 18 – Albert II, Margrave of Brandenburg-Ansbach, German prince (d. 1625)
- September 29 – John Louis of Elderen (d. 1694)
- October 1 – Nicolaes Pieterszoon Berchem, Dutch Golden Age painter of pastoral landscapes (d. 1683)
- October 4 – François-Henri Salomon de Virelade, French lawyer (d. 1670)
- October 15 – William Borlase (died 1665), English politician (d. 1665)
- October 16 – Pierre Paul Puget, French painter (d. 1694)
- October 20 – Aelbert Cuyp, Dutch painter (d. 1691)
- October 27 – Philip Louis, Duke of Schleswig-Holstein-Sonderburg-Wiesenburg (d. 1689)
- October 31 – John Evelyn, English diarist and writer (d. 1706)
- November 10
- November 20 – Peregrine White, first English child born at Plymouth Colony (d. 1704)
- December 17
- December 18 – Heinrich Roth, missionary and pioneering Sanskrit scholar (d. 1668)
- December 23 – Johann Jakob Wepfer, Swiss pathologist (d. 1695)