17Beta Hydroxysteroid dehydrogenase
| 17β-Hydroxysteroid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.51 | ||||||||
| CAS number | Template:CAS | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
|
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17β-Hydroxysteroid dehydrogenases (EC 1.1.1.51, beta-hydroxy steroid dehydrogenase, 17-ketoreductase, 17beta-hydroxy steroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxy steroid dehydrogenase, 17β-HSD, 17-ketosteroid oxidoreductases, HSD17B, 17-ketosteroid reductases, 17-KSR), are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis.[1][2][3][4][5] This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol, respectively.[6][7]
Note that the major reactions catalysed by 17β-HSD (e.g., the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.
Genes
Genes coding for 17β-HSD include:
- HSD17B1
- HSD17B2
- HSD17B3
- HSD17B4
- HSD17B6
- HSD17B7
- HSD17B8
- HSD17B10
- HSD17B11
- HSD17B12
- HSD17B13
- HSD17B14
Clinical significance
Isozyme 3 is responsible for 17-beta-hydroxysteroid dehydrogenase deficiency.
References
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- 17 beta-Hydroxysteroid Dehydrogenases at the US National Library of Medicine Medical Subject Headings (MeSH)
External links
- 3(or 17)beta-hydroxysteroid dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
