The following are the baseball events of the year 1922 throughout the world.
Major league baseball final standings
American League final standings
National League final standings
Negro League Baseball final standings
Negro National League final standings
East (independent teams) final standings
A loose confederation of teams were gathered in the East to compete with the West, however East teams did not organize a formal league as the West did.
- April 9 – With a St. Louis record crowd of 29,000 on hand, the Browns top the Cardinals, 6–3, to win their City Series.
- April 12 – The Chicago Cubs win their season opener 7-3 over the Cincinnati Reds. Hall of Fame catcher Gabby Hartnett debuts behind the plate for the Cubs.
- April 18 – St. Louis Cardinals pitcher Sid Benton faces two batters in the Cards' 7–5 loss to the Chicago Cubs, and walks both. It is his only major league experience ever.
- April 30 – In his fourth career start, Chicago White Sox pitcher Charlie Robertson pitches the fifth perfect game in Major League history. Chicago tops the Detroit Tigers, 2–0, at Navin Field in Detroit.
- May 7 – Jesse Barnes of the New York Giants pitches a no-hitter in a 6–0 win over the Philadelphia Phillies.
- May 20 – Babe Ruth joins the New York Yankees after having been suspended for an illegal barnstorming tour the previous fall.
- June 5 – In the only game on the Major League schedule, sloppy play by the St. Louis Cardinals is the difference in the Boston Braves' 6–0 victory. An error by Cardinals first baseman Jack Fournier leads to two unearned runs in the second. With two outs in the third, Jeff Pfeffer walks one, then gives up consecutive singles for Boston's third run. Hod Ford's single to center drives in a fourth run, followed by an error by center fielder Jack Smith, leading to a fifth run. Fournier commits a second error in the fifth which leads to Boston's sixth, and final, run.
- July 6 – The New York Yankees pound the Cleveland Indians in both games of a doubleheader by scores of 10–3 and 11–3. Babe Ruth drives in four runs in the first game, and is held hitless in the second.
- July 23 – Chicago Cubs first baseman Ray Grimes drives in two runs in a 4–1 victory over the Brooklyn Dodgers, giving him at least one RBI in seventeen straight games.
- August 15 – The Chicago White Sox defeated the Boston Red Sox at Fenway Park, 19–11, in a game which both teams combined for a whopping 35 singles. Chicago collected 21 singles, Boston 14, to set an American League record that's still intact.
- August 18 – The St. Louis Cardinals defeat the Philadelphia Phillies 3–2 in fourteen innings. Future Hall of Famer Jim Bottomley makes his major league debut for the Cardinals playing all fourteen innings.
- August 25 – In the first game of a double header, New York Yankees pitcher Waite Hoyt holds St. Louis Browns slugger Ken Williams hitless, snapping his 28-game hitting streak. The Browns win regardless, 3–1.
- September 16 – The St. Louis Browns open a crucial three game set against the New York Yankees at Sportsman's Park. The Yankees win game one of the series, 2–1, behind a strong pitching effort from Bob Shawkey.
- September 23 – Future Hall of Famer Kiki Cuyler makes his only appearance of the season in the Pittsburgh Pirates 5–1 loss to the Brooklyn Dodgers.
- September 27 – Future Hall of famer Travis Jackson makes his Major league debut with the New York Giants, striking out in his only at-bat in the Giants' 3–2 victory over the Philadelphia Phillies.
- September 30 – Philadelphia Athletics pitcher Eddie Rommel gets his league leading 27th victory over the Washington Senators. Philadelphia only manage 65 victories all season, and finish in seventh place in the American League.
- October 1 – St. Louis Cardinals second baseman Rogers Hornsby goes three-for-five to end the season with a .401 batting average, becoming the first National Leaguer to end the season with a .400 average since 1901. Horsnby also sets new National League records with 42 home runs, 152 runs batted in, and a .722 slugging percentage.
- October 4 – For the second year in a row, every game of the World Series is played at the Polo Grounds in New York City since it houses both the Giants and Yankees. The Giants score three in the eighth inning to take game one, 3–2.
- October 5 – After ten innings, game two of the 1922 World Series is declared a 3-3 tie.
- October 6 – Behind a four hitter by Jack Scott, the Giants win game three of the World Series, 3-0.
- October 7 – A four run fifth inning carries the Giants to a 4–3 victory over the Yankees in game four of the World Series.
- October 8 – The New York Giants defeat the New York Yankees, 5–3, in Game five of the World Series, to win their second consecutive World Championship, and third overall, with a 4-0-1 record.
- November 1 – former Philadelphia Athletics catcher Ira Thomas buys the Shreveport Gassers Texas League club for $75,000. Other former players who own pieces of minor league clubs include Ty Cobb (Augusta Georgians), Eddie Collins (Baltimore Orioles), and George Stallings (Rochester Red Wings).
- January 11 – Miah Murray, 57, catcher for the Nationals, Colonels, Grays and Statesmen between 1884 and 1891, who became a full-time umpire in 1895.
- January 14 – Ben Shibe, 83, owner of the Philadelphia Athletics since the 1901 season, during which period the team won six American League pennants and three World Series.
- January 19 – Bob Keating, 59, pitcher for the 1887 Baltimore Orioles.
- January 21 – Orator Shafer, 70, outfielder for 13 seasons from 1874 to 1890, who collected a .282 batting average and 1000 hits in 871 career games.
- January 27 – Emil Frisk, 47, pitcher and outfielder in four major league seasons between 1899 and 1907, who became the first player to accumulate over 2,000 hits in minor league history.
- January 30 – Billy Rhines, 52, pitcher who posted a 114-103 record for three teams between 1890 and 1899, while leading the National League in earned run average in the 1890 and 1896 seasons.
- February 6 – Frank Barrows, 77, outfielder for the 1871 Boston Red Stockings.
- February 15 – Pete Childs, 50, infielder who played from 1901 through 1902 for the St. Louis Cardinals, Chicago Orphans and Philadelphia Phillies.
- February 22 – George Hogan, 36, pitcher for the 1914 Kansas City Packers of the Federal League.
- February 23 – Pickles Dillhoefer, 28, catcher who played from 1917 to 1921 with the Chicago Cubs, Philadelphia Phillies and St. Louis Cardinals.
- February 23 – C. I. Taylor, 47, owner and manager of the Negro Leagues' Indianapolis ABC's since 1914, co-founder of the Negro National League.
- February 28 – Walt Walker, 61, catcher for the 1884 Detroit Wolverines of the National League.
- March 11 – Joe Gerhardt, 67, second baseman for several teams from 1873 to 1891, who led the National League in assists twice and in double plays three times.
- March 14 – Danny Hoffman, 42, center fielder for the Athletics, Highlanders and Browns from 1903 through 1911, who led the American League in stolen bases during the 1905 season.
- March 26 – Count Gedney, 72, left fielder who played from 1872 through 1875 for the Mutuals, Athletics, Eckfords and Haymakers of the National Association.
- April 1 – Leech Maskrey, 68, left fielder for the Louisville Eclipse/Colonels and the Cincinnati Red Stockings from 1882 to 1886.
- April 1 – Harry Smith, 31, catcher for the New York Giants, Brooklyn Tip-Tops and Cincinnati Reds between 1914 and 1918.
- April 14 – Cap Anson, 69, Hall of Fame first baseman for the Chicago White Stockings who was the 19th century's most prolific hitter, setting career records for games, hits, runs, doubles and RBI; batted .333 lifetime, winning three batting titles, also ranked sixth all-time in home runs upon retirement; managed Chicago to five pennants (1880–82, 1885–86), 1296 career victories were record until 1907; among first managers to use pitching rotation, and first to organize spring training.
- May 19 – Bob Reach, 78, National Association shortstop who played from 1872 to 1873 for the Olympics and Blue Legs teams based in Washington, D.C..
- May 22 – Bill Daley, 53, pitcher for three seasons; one for the Boston Beaneaters, and two for the Boston Reds.
- May 24 – Charlie Frank, 61, outfielder for the St. Louis Browns from 1893 to 1894.
- May 25 – Charlie Gessner, 58, pitcher for the 1886 Philadelphia Athletics of the American Association.
- May 31 – John Coleman, 59, pitcher/outfielder for the Pittsburgh Alleghenys and the Quakers/Athletics Philadelphia teams between 1883 and 1890, who led all National League pitchers in starts, complete games and innings pitched during the 1883 season.
- June 12 – Chief Johnson, 36, pitcher who played from 1913 to 1914 for the Cincinnati Reds of the National League and the Kansas City Packers of the Federal League.
- June 24 – Dan O'Leary, 65, outfielder from 1879–1884, player-manager for the 1884 Cincinnati Outlaw Reds of the Union Association.
- June 28 – Dick Lowe, 68, catcher for the 1884 Detroit Wolverines of the National League.
- July 4 – John Pickett, 56, second baseman/outfielder for three seasons from 1889 to 1892.
- July 10 – Harvey Bailey, 45, pitcher who played for the Boston Beaneaters of the National League in 1899 and 1900.
- July 15 – Charlie Kuhns, 46, National League infielder for the Pittsburgh Pirates (1897) and the Boston Beaneaters (1899).
- July 20 – Dick Pierson, 64, first baseman for the 1885 New York Metropolitans of the American Association.
- July 27 – Nig Cuppy, 53, pitcher who won 24 or more games four times for the Cleveland Spiders.
- August 5 – Tommy McCarthy, 59, Hall of Fame outfielder for the St. Louis and Boston teams who batted .300 four times and pioneered several strategies; defensive standout led American Association in assists and steals once each.
- August 12 – Sam King, 70, first baseman for the 1884 Washington Nationals of the American Association.
- September 15 – Charlie Jones, 60, infielder who played for the 1884 Brooklyn Atlantics.
- September 18 – Jake Stahl, 43, manager and first baseman who led the Red Sox to the 1912 World Series title, led AL in home runs in 1910.
- September 23 – Butch Rementer, 44, catcher for the 1904 Philadelphia Phillies.
- September 30 – Frank Genins, 56, infielder/outfielder who played for the Cincinnati Reds, St. Louis Browns, Pittsburgh Pirates and Cleveland Blues between 1892 and 1901.
- October 14 – Rasty Wright, 59, outfielder who played in 1890 with the Syracuse Stars of the American Association and the Cleveland Spiders of the National League.
- October 25 – Pat Kilhullen, 32, catcher for the 1914 Pittsburgh Pirates.
- October 31 – Dick Padden, 52, second baseman who hit .258 in 824 games Pirates, Senators, Cardinals and Browns between 1896 and 1905.
- November 1 – Billy Goeckel, 51, first baseman for the 1899 Philadelphia Phillies.
- November 4 – John Houseman, 52, Dutch infielder/outfielder who played with the Chicago Cubs in 1894 and for the St. Louis Cardinals in 1897.
- November 6 – Morgan G. Bulkeley, 84, executive who served as the National League's first president in 1876, also as president of Hartford club; later a governor of Connecticut and U.S. Senator.
- November 7 – Sam Thompson, 62, Hall of Fame right fielder for Detroit and Philadelphia who batted .331 lifetime and won 1887 batting title; led National League in hits three times, home runs and doubles twice each; until 1921, held record of 166 RBI (1887) and ranked second in career home runs; his .505 career slugging average was second highest of 19th century.
- November 11 – Dave Pierson, 67, catcher/outfielder for the 1876 Cincinnati Reds.
- November 14 – Doc Oberlander, 58, pitcher for the 1888 Cleveland Blues of the American Association.
- November 18 – Len Lovett, 70, outfielder for the Elizabeth Resolutes (1873) and Philadelphia Centennials (1875) National Association teams.
- November 23 – Sandy McDermott, 66, second baseman for the 1885 Baltimore Orioles of the American Association.
- November 27 – Austin McHenry, 27, dies from a brain tumor after hitting .350 with 17 home runs and 110 RBI for the 1921 St. Louis Cardinals, who became ill during the 1922 season and was hitting .303 when forced to quit.
- December 1 – Jim Snyder, 75, catcher/shortstop for the Brooklyn Eckfords of the National Association between 1870 and 1872.
- December 22 – Dad Meek, 55, catcher who played from 1889 through 1890 for the St. Louis Browns of the American Association.
- December 25 – Wes Fisler, 81, infielder/outfielder who hit .310 for the Philadelphia Athletics from 1871 to 1876, and a member of the 1871 National Association champion team.