2'-O-methylation
2'-O-methylation is a common nucleoside modification of RNA, where a methyl group is added to the 2' hydroxyl of the ribose moiety of a nucleoside, producing a methoxy group. 2'-O-methylated nucleosides are mostly found in ribosomal RNA and small nuclear RNA and occur in the functionally essential regions of the ribosome and splicesome.[1] Also, 2'-O-methylation of adenosine in an RNA prevents adenosine deaminase from editing it to an inosine.[2]
Recently a novel method to map 2'-O ribose methylations by high throughput sequencing has been published. [3] The method is quantitative and maps all modifications in a single experiment.
See also
References
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