2,3-Dimercapto-1-propanesulfonic acid

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
2,3-Dimercapto-1-propanesulfonic acid
200px
230px
Identifiers
207233-91-8 N
ChEBI CHEBI:888 YesY
ChemSpider 6081 YesY
Jmol 3D model Interactive image
Interactive image
KEGG C10922 YesY
MeSH Unithiol
PubChem 6321
  • InChI=1S/C3H8O3S3/c4-9(5,6)2-3(8)1-7/h3,7-8H,1-2H2,(H,4,5,6) YesY
    Key: JLVSRWOIZZXQAD-UHFFFAOYSA-N YesY
  • InChI=1/C3H8O3S3/c4-9(5,6)2-3(8)1-7/h3,7-8H,1-2H2,(H,4,5,6)
    Key: JLVSRWOIZZXQAD-UHFFFAOYAD
  • OS(=O)(=O)CC(S)CS
  • O=S(=O)(O)CC(S)CS
Properties
C3H8O3S3
Molar mass 188.289 g/mol
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) and its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals. They are related to dimercaprol, which is another chelating agent.

The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin.[1] The effects of DMPS on heavy metal poisoning, including with polonium-210, were investigated in the following years. DMPS was found to have some protective effect, prolonging the survival time.[2]

A study was undertaken of DMPS use by workers involved in the production of a calomel skin bleaching lotion and in direct contact with mercurous chloride and that already showed elevated urine mercury levels. The sodium salt of DMPS was found to be effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels.[3]

DMPS administrated to a mercury poisoned animal model failed to remove the mercury from tissues and reduce the inorganic mercury burden in the brain.[4][5] A 2008 study reported a case of Stevens–Johnson syndrome (SJS), a potentially serious disease, in a child undergoing chelation therapy with DMPS; the SJS resolved gradually after the chelation therapy was stopped.[6]

See also

References

  1. Lua error in package.lua at line 80: module 'strict' not found.
  2. Lua error in package.lua at line 80: module 'strict' not found.
  3. Lua error in package.lua at line 80: module 'strict' not found.
  4. Lua error in package.lua at line 80: module 'strict' not found.
  5. Lua error in package.lua at line 80: module 'strict' not found.
  6. Lua error in package.lua at line 80: module 'strict' not found.