2,6-Diaminopurine
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| Names | |
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| IUPAC name
7H-Purine-2,6-diamine
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| Other names
2-Aminoadenine
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| Identifiers | |
1904-98-9  |
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| ChEMBL | ChEMBL388596  = |
| ChemSpider | 28738 |
| Jmol 3D model | Interactive image |
| PubChem | 30976 |
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| Properties | |
| C5H6N6 | |
| Molar mass | 150.15 g·mol−1 |
| Appearance | White to yellow crystalline powder |
| Density | 1.743 g/cm3 |
| Melting point | 117 to 122 °C (243 to 252 °F; 390 to 395 K) |
| 2.38 g/L at 20 °C | |
| Vapor pressure | {{{value}}} |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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 (what is ?) |
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| Infobox references | |
2,6-Diaminopurine is a compound used to treat leukemia.[1]
In August 2011, a report, based on NASA studies with meteorites found on Earth, was published suggesting 2,6-diaminopurine and related organic molecules, including the DNA and RNA components adenine and guanine, may have been formed extraterrestrially in outer space.[1][2][3]
Cyanophage S-2L
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In Cyanophage S-2L, diaminopurine (DAP) is used instead of adenine (host evasion).[4] Diaminopurine basepairs perfectly with thymine as it is identical to adenine but has an amine group at position 2 forming 3 intramolecular hydrogen bonds, eliminating the major difference between the two types of basepairs (Weak:A-T and Strong:C-G). This improved stability affects protein-binding interactions that rely on those differences.
References
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- ↑ Kirnos MD, Khudyakov IY, Alexandrushkina NI, Vanyushin BF. 2-aminoadenine is an adenine substituting for a base in S-2L cyanophage DNA. Nature. 1977 Nov 24;270(5635):369–70.
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