The 2006 Coppa Italia Final was a double match played between Roma and Internazionale. The first leg was played in Rome on 3 May 2006, while the second leg on 11 May.
Inter won the trophy with an aggregate result of 4–2.
With this victory, Internazionale manager Roberto Mancini won the Coppa Italia for the tenth time, six as a player, four as a coach.
This was the second final between these two clubs, the match being the replay of previous season's final act.
Generally speaking, Roma played here its thirteenth final, while Inter its ninth one.