ABCB8
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| ATP-binding cassette, sub-family B (MDR/TAP), member 8 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ABCB8 ; EST328128; M-ABC1; MABC1 | ||||||||||||
| External IDs | OMIM: 605464 MGI: 1351667 HomoloGene: 5203 GeneCards: ABCB8 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11194 | 74610 | |||||||||||
| Ensembl | ENSG00000197150 | ENSMUSG00000028973 | |||||||||||
| UniProt | Q9NUT2 | Q9CXJ4 | |||||||||||
| RefSeq (mRNA) | NM_001282291 | NM_029020 | |||||||||||
| RefSeq (protein) | NP_001269220 | NP_083296 | |||||||||||
| Location (UCSC) | Chr 7: 151.03 – 151.05 Mb |
Chr 5: 24.39 – 24.41 Mb |
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| PubMed search | [1] | [2] | |||||||||||
ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene.[1][2]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.[2]
See also
- ATP-binding cassette transporter
- ABCB8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
References
Further reading
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External links
- ABCB8 human gene location in the UCSC Genome Browser.
- ABCB8 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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