Actinin, alpha 1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.[1]
Function
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.[2]
Interactions
Actinin, alpha 1 has been shown to interact with:
- CDK5R1,[3]
- CDK5R2,[3]
- Collagen, type XVII, alpha 1,[4]
- GIPC1,[5]
- PDLIM1,[6][7]
- Protein kinase N1,[8]
- SSX2IP,[9] and
- Zyxin.[10][11]
- PTPRT(PTPrho)[12]
See also
References
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Further reading
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External links
- Actinin, alpha 1 Info with links in the Cell Migration Gateway
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