Acetohydroxamic acid

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Acetohydroxamic acid
File:Acetohydroxamic acid.svg
File:Acetohydroxamic-acid-3D-balls.png
Systematic (IUPAC) name
ethanehydroxamic acid
Clinical data
AHFS/Drugs.com Consumer Drug Information
Identifiers
CAS Number 546-88-3 YesY
ATC code G04BX03 (WHO)
PubChem CID: 1990
DrugBank DB00551 YesY
ChemSpider 1913 YesY
UNII 4RZ82L2GY5 YesY
KEGG D00220 YesY
ChEBI CHEBI:49029 YesY
ChEMBL CHEMBL734 YesY
Chemical data
Formula C2H5NO2
Molecular mass 75.0666 g/mol
  • O=C(NO)C
  • InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4) YesY
  • Key:RRUDCFGSUDOHDG-UHFFFAOYSA-N YesY
  (verify)

Acetohydroxamic acid (also known as AHA or Lithostat) is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme.[1]

Orphan drug

In 1983 the US Food and Drug Administration approved acetohydroxamic acid (AHA) as an orphan drug for "prevention of so-called struvite stones" under the newly enacted Orphan Drug Act of 1983.[2] AHA cannot be patented because it is a standard chemical compound.[2]

References

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See also


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