Acetohydroxamic acid
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File:Acetohydroxamic acid.svg | |
File:Acetohydroxamic-acid-3D-balls.png | |
Systematic (IUPAC) name | |
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ethanehydroxamic acid
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Clinical data | |
AHFS/Drugs.com | Consumer Drug Information |
Identifiers | |
CAS Number | 546-88-3 |
ATC code | G04BX03 (WHO) |
PubChem | CID: 1990 |
DrugBank | DB00551 |
ChemSpider | 1913 |
UNII | 4RZ82L2GY5 |
KEGG | D00220 |
ChEBI | CHEBI:49029 |
ChEMBL | CHEMBL734 |
Chemical data | |
Formula | C2H5NO2 |
Molecular mass | 75.0666 g/mol |
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Acetohydroxamic acid (also known as AHA or Lithostat) is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme.[1]
Orphan drug
In 1983 the US Food and Drug Administration approved acetohydroxamic acid (AHA) as an orphan drug for "prevention of so-called struvite stones" under the newly enacted Orphan Drug Act of 1983.[2] AHA cannot be patented because it is a standard chemical compound.[2]
References
See also
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