Acrivastine

Acrivastine

Systematic (IUPAC) name
(E)-3-{6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl- prop-1-enyl]pyridin-2-yl}prop-2-enoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682619
Pregnancy category	US: B (No risk in non-human studies)
Legal status	UK: General sales list (GSL, OTC) US: ℞-only
Routes of administration	oral
Pharmacokinetic data
Biological half-life	1.5 hours
Excretion	Renal
Identifiers
CAS Number	87848-99-5 N
ATC code	R06AX18 (WHO)
PubChem	CID: 5284514
ChemSpider	4447574 Y
UNII	A20F9XAI7W Y
KEGG	D02760 Y
ChEBI	CHEBI:83168 N
ChEMBL	CHEMBL1224 Y
Chemical data
Formula	C22H24N2O2
Molecular mass	348.438 g/mol
SMILES O=C(O)\C=C\c3nc(\C(=C\CN1CCCC1)c2ccc(cc2)C)ccc3
InChI InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+ Y Key:PWACSDKDOHSSQD-IUTFFREVSA-N Y
NY (what is this?)  (verify)

Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors.

This non-sedating antihistamine is sold under the brand name Benadryl Allergy Relief in the United Kingdom by McNeil Laboratories. It should not be confused with Benadryl Once a Day which has cetirizine as the active ingredient and is also sold by McNeil in the UK. It is available as an over-the-counter medicine in the UK, and is available with or without pseudoephedrine under the Benadryl brand.

In the U.S., acrivastine is the active ingredient in the Semprex brand. Semprex-D also contains the decongestant pseudoephedrine. Semprex-D is marketed in the U.S. by Actient Pharmaceuticals.

Comparisons with other popular antihistamines

Unlike cetirizine or loratadine, for which the standard dose is one tablet per day, a single acrivastine tablet may be taken up to three times a day. It is not to be taken by over 65s, pregnant women, or people with compromised liver or kidney function.