Acrosin

acrosin
File:Acrosin-1FIW.png
Identifiers
EC number	3.4.21.10
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Acrosin
Identifiers
Symbol	ACR
External IDs	OMIM: 102480 MGI: 87884 HomoloGene: 855 IUPHAR: 2327 ChEMBL: 2738 GeneCards: ACR Gene
EC number	3.4.21.10
Gene ontology Molecular function • DNA binding • amidase activity • serine-type endopeptidase activity • copper ion binding • protein binding • mannose binding • drug binding • zinc ion binding • fucose binding Cellular component • extracellular region • nucleus • Golgi-associated vesicle • acrosomal matrix • protein complex Biological process • acrosome matrix dispersal • activation of adenylate cyclase activity • single fertilization • binding of sperm to zona pellucida • acrosome reaction • penetration of zona pellucida • multicellular organism reproduction • response to steroid hormone Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	49	11434
Ensembl	ENSG00000100312	ENSMUSG00000022622
UniProt	P10323	P23578
RefSeq (mRNA)	NM_001097	NM_001205049
RefSeq (protein)	NP_001088	NP_001191978
Location (UCSC)	Chr 22: 50.74 – 50.75 Mb	Chr 15: 89.57 – 89.57 Mb
PubMed search	[1]	[2]

Acrosin is a digestive enzyme that acts as a protease. In humans, acrosin is encoded by the ACR gene. Acrosin is released from the acrosome of spermatozoa as a consequence of the acrosome reaction. It aids in the penetration of the Zona Pellucida.

Function

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.223
• Acrosin at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.