Addressin

Mucosal vascular addressin cell adhesion molecule 1
250px Crystallographic structure of human mucosal addressin cell adhesion molecule 1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BQS, 1GSM, 4HBQ, 4HC1, 4HCR, 4HD9
Identifiers
Symbols	MADCAM1 ; MACAM1
External IDs	OMIM: 102670 MGI: 103579 HomoloGene: 8413 ChEMBL: 4467 GeneCards: MADCAM1 Gene
Gene ontology Molecular function • integrin binding involved in cell-matrix adhesion Cellular component • plasma membrane • membrane • integral component of membrane Biological process • positive regulation of leukocyte migration • immune response • cell adhesion • cell-matrix adhesion • signal transduction • integrin-mediated signaling pathway • aging • extracellular matrix organization • keratinocyte differentiation • heterotypic cell-cell adhesion • receptor clustering • regulation of immune response • leukocyte tethering or rolling Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8174	17123
Ensembl	ENSG00000099866	ENSMUSG00000020310
UniProt	Q13477	Q61826
RefSeq (mRNA)	NM_130760	NM_013591
RefSeq (protein)	NP_570116	NP_038619
Location (UCSC)	Chr 19: 0.49 – 0.51 Mb	Chr 10: 79.66 – 79.67 Mb
PubMed search	[1]	[2]

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.

Addressin is an extracellular protein of the endothelium of venules. Addressins are the ligands to the homing receptors of lymphocytes. The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. They carry carbohydrates in order to be recognized by L-selectin.

Function

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.

See also

• CD34
• GLYCAM1

External links

• vascular addressins at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.