Amrubicin
From Infogalactic: the planetary knowledge core
Systematic (IUPAC) name | |
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(7S,9S)-9-Acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione
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Clinical data | |
AHFS/Drugs.com | International Drug Names |
Legal status |
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Routes of administration |
IV |
Identifiers | |
CAS Number | 110267-81-7 |
ATC code | L01DB10 (WHO) |
PubChem | CID: 178149 |
ChemSpider | 2299344 |
UNII | 93N13LB4Z2 |
KEGG | D08854 |
ChEMBL | CHEMBL1186894 |
Chemical data | |
Formula | C25H25NO9 |
Molecular mass | 483.46 g/mol |
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Amrubicin (INN; previously known as SM-5887) is an anthracycline used in the treatment of lung cancer.[1] It is marketed in Japan since 2002 by Sumitomo under the brand name Calsed.[2]
Amrubicin acts by inhibiting topoisomerase II, and has been compared in clinical trials with topotecan, a Topoisomerase I inhibitor.[3][4]
It has also been studied for the treatment of bladder carcinoma[5] and gastric cancer.[6]
Amrubicin was the first anthracycline derivative created by de novo synthesis and was first published in 1989 by scientists from Sumitomo.[7]
References
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- ↑ Hanada M. Amrubicin, Chapter 6 in Case Studies in Modern Drug Discovery and Development. Eds. Huang X and Aslanian RG. John Wiley & Sons, 2012 ISBN 9780470601815 P 106
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Categories:
- Articles with dead external links from October 2010
- Drugs with non-standard legal status
- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Chemical pages without DrugBank identifier
- Anthracyclines
- Ketones
- Alcohols
- Quinones
- Antineoplastic and immunomodulating drug stubs