Upon leaving drama college, her first professional stage role was playing opposite Andrew Keir in The Bigot. She has worked in many of the major Scottish theatres. Highlights from her theatre career include: Six Black Candles (Royal Lyceum, garnering the Critics Award for Best Ensemble), Tally's Blood (Traverse), Just Frank (Traverse), Can't Pay Won't Pay! (TAG), Marching On (7:84), and roles in pantomime with comedy legends Stanley Baxter and Jimmy Logan. She appeared as Granny Morrison in Josie Rourke's revival of Ena Lamont Stewart's Men Should Weep at the Royal National Theatre, London.
Her film credits include: 16 Years of Alcohol, Solstice, The Crews, and Running in Traffic (nominated for Michael Powell and BAFTA awards, screened at the Edinburgh International Festival and winner of the Apollo Prize).
Her novel The Witches of Pollok was published by Capercaillie Books on 6 October 2010.
She also has written non-fiction including: On Being an Actor (Chapman), China Diary (Herald) and On having Irish Roots (Argyle Press).
Her works as a playwright include: Waiting on One (winner of Thames Television award), published by Fairplay Press, 2007; The White Bird Passes (adapted from the novel by Jessie Kesson). Published by Fairplay Press, 2007 and The Female of The Species Published by Fairplay Press, 2007.
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- "Anne Downie". Film Rights Ltd. Retrieved 21 September 2014.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- Downie, Annie. "Across the Water - Article by Anne Downie". wigtown-booktown.co.uk. Retrieved 21 September 2014.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>