Apolipoprotein C2

Apolipoprotein C-II
PDB rendering based on 1by6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BY6, 1I5J, 1O8T, 1SOH
Identifiers
Symbols	APOC2 ; APO-CII; APOC-II
External IDs	OMIM: 608083 MGI: 88054 HomoloGene: 47928 GeneCards: APOC2 Gene
Gene ontology Molecular function • lipid binding • phospholipase activator activity • protein homodimerization activity • phospholipase binding • lipase inhibitor activity • lipoprotein lipase activator activity Cellular component • extracellular region • extracellular space • early endosome • very-low-density lipoprotein particle • low-density lipoprotein particle • intermediate-density lipoprotein particle • spherical high-density lipoprotein particle • chylomicron • extracellular exosome Biological process • retinoid metabolic process • phototransduction, visible light • positive regulation of phospholipase activity • positive regulation of triglyceride catabolic process • positive regulation of very-low-density lipoprotein particle remodeling • negative regulation of very-low-density lipoprotein particle clearance • lipid catabolic process • negative regulation of cholesterol transport • cholesterol efflux • phospholipid efflux • triglyceride-rich lipoprotein particle remodeling • chylomicron remodeling • very-low-density lipoprotein particle remodeling • chylomicron remnant clearance • high-density lipoprotein particle clearance • lipoprotein metabolic process • cholesterol homeostasis • negative regulation of catalytic activity • reverse cholesterol transport • small molecule metabolic process • positive regulation of fatty acid biosynthetic process • negative regulation of lipid metabolic process • negative regulation of receptor-mediated endocytosis • positive regulation of lipoprotein lipase activity • positive regulation of phospholipid catabolic process • triglyceride homeostasis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	344	11813
Ensembl	ENSG00000224916	ENSMUSG00000002992
UniProt	P02655	Q05020
RefSeq (mRNA)	NM_000483	NM_001277944
RefSeq (protein)	NP_000474	NP_001264873
Location (UCSC)	Chr 19: 44.94 – 44.95 Mb	Chr 7: 19.67 – 19.68 Mb
PubMed search	[1]	[2]

Apo-CII
File:PDB 1i5j EBI.jpg nmr structure of human apolipoprotein c-ii in the presence of sds
Identifiers
Symbol	Apo-CII
Pfam	PF05355
InterPro	IPR008019
SCOP	1by6
SUPERFAMILY	1by6
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|px|alt=Statin Pathway edit]]

File:StatinPathway_WP430.png

Statin Pathway edit

See also

• Apolipoprotein C