Filomarino was born in Naples of the noble family of the dukes Della Torre. Eldest of the five sons of Claudio Filomarino and Porzia di Leonessa. Though the family was well-respected, it was nonetheless not a wealthy family. Filomarino was, though, able to obtain a doctorate of law in Benevento and thereafter travelled to Rome (with friend Ladislao d'Aquino who would also later become a cardinal) in an effort to support himself financially.
There he presented himself to a number of cardinals with a view to being employed by one of them. Eventually he came to the attention of Cardinal Maffeo Barberini who was in need of a new chamberlain. In 1623, Barberini was elected to the papacy and took the name Pope Urban VIII and thereafter Filomarino became master of the chamber to the pope's young cardinal-nephew, Francesco Barberini, while he was legate to France and Spain.
Francesco did not like his older tutor - or did not like having a tutor at all. But Filomarino was protected by the young cardinal's uncle, the pope, who had promised to promote Filomarino to the rank of cardinal. Barberini, though keen to be rid of his supervision, was loath to see Filomarino elevated to the same status as himself and insisted that the tutor was still essential. Eventually Barberini gave in and Filomarino was allowed to leave his service and was promoted.
Filomarino's role in the revolt of 1647 was one of mediation between the rebels and the government. He was outspoken in his opposition to increasing taxation in the Spanish vice-realm of Naples, monies that the Spanish needed to pay for their part in the Thirty Years War. He was a focal point for the people against the overbearing Spanish throne and was trusted by the rebel Masaniello as well as by Giulio Genoino, the apparent real political strategist behind the revolt. As cardinal, however, he was part of the establishment and could approach the government; thus, he was in an ideal position to mediate.
Filomarino certainly was aware of popular discontent in Naples and warned the Pope that the masses were "boiling".
Some sources  claim that Filomarino was primarily interested in reducing the power of the large landed Spanish noble class in favor of the growing, but overtaxed, merchant middle class in Naples. Further — so they claim — when Filomarino had used Masaniello to that end, he arranged to have the rebel delivered into the hands of captors, where he was murdered. Such a claim is impossible to substantiate.
There are a number of anecdotes about Filomarino. One is that during the plague of 1656, he ordered the churches to care for the stricken, yet apparently was among the first to seek refuge in the monastery of San Martino. Another was that he had to be reminded by Rome that the sacred relics of San Gennaro (Saint Januarius), patron saint of the city, were not his own personal property and that he was not authorized to claim, as he had, that "…the relics are mine…", nor authorized to remove them from the premises of the Cathedral of Naples for the purpose of soliciting miraculous cures in private homes.
Cardinal Filomarino died on November 3, 1666, and is buried in the cathedral of Naples.
- S. Miranda: Cardinals of the Holy Roman Church
- Pope Alexander the Seventh and the College of Cardinals by John Bargrave, edited by James Craigie Robertson (reprint; 2009)
- See Filomarino to Innocent X, 8 July 1647 in "Sette lettere del cardinal Filomarino al papa", ed. Palermo, p. 381. Cited in Burke. P. 7
- di Rose, p 55, citing Storia di Napoli by Antonio Ghirelli (1973)
- Renzi, Napoli, p. 62. Cited in di Rose, p. 55
- di Rose
- Burke, Peter (May 1983). "The Virgin of the Carmine and the Revolt of Masaniello". Past and Present. 99: 3–21. doi:10.1093/past/99.1.3.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- di Rose, Aurelio (2001). I Palazzi di Napoli. Rome: Newton & Compton editori. ISBN 978-88-8289-637-9.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- Renzi, Salvatore (1968). Napoli nell'anno 1656. Rome.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- Villari, Rosario (August 1985). "Masaniello: Contemporary and Recent Interpretations". Past and Present. 108: 117–132. doi:10.1093/past/108.1.117.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>