Asialoglycoprotein receptor

asialoglycoprotein receptor 1
Identifiers
Symbol	ASGR1
Entrez	432
HUGO	742
OMIM	108360
RefSeq	NM_001671
UniProt	P07306
Other data
Locus	Chr. 17 p13-p11

asialoglycoprotein receptor 2
Identifiers
Symbol	ASGR2
Entrez	433
HUGO	743
OMIM	108361
RefSeq	NM_080914
UniProt	P07307
Other data
Locus	Chr. 17 p

The asialoglycoprotein receptors are lectins which bind asialoglycoprotein, glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are located on liver cells, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes and several human carcinoma cell lines. Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.

External links

• Asialoglycoprotein receptor at the US National Library of Medicine Medical Subject Headings (MeSH)