Assisted zona hatching
Assisted zona hatching (AZH) is a procedure of assisted reproductive technology in which a small hole is made in the zona pellucida, using a micromanipulator, thereby facilitating for zona hatching to occur.[1][1] Zona hatching is where the blastocyst gets rid of the surrounding zona pellucida to be able to implant in the uterus.
Efficacy
A systematic review and meta-analysis came to the result that assisted zona hatching is related to increased rates of clinical pregnancy and multiple pregnancy in women with previous repeated failure or frozen-thawed embryos.[2] However, it is unlikely to increase clinical pregnancy rates when performed in fresh embryos transferred to unselected women, to those without poor prognosis or to women of advanced maternal age.[2] Also, overall, there no evidence of a significant difference in live birth rate following assisted hatching compared with no assisted hatching.[3]
References
- ↑ 1.0 1.1 IVF-infertility.com
- ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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