BD1008

BD1008

Systematic (IUPAC) name
N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-1-pyrrolidineethanamine
Identifiers
CAS Number	138356-08-8
PubChem	CID: 126388
ChemSpider	112324
Chemical data
Formula	C15H22Cl2N2
Molecular mass	301.25 g/mol
SMILES CN(CCc1ccc(c(c1)Cl)Cl)CCN2CCCC2
InChI InChI=1S/C15H22Cl2N2/c1-18(10-11-19-7-2-3-8-19)9-6-13-4-5-14(16)15(17)12-13/h4-5,12H,2-3,6-11H2,1H3 Key:ASGIQUHBAVIOTI-UHFFFAOYSA-N

BD1008 or N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor.

Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1008 significantly attenuates the behavioral toxicity of cocaine, and may be potentially useful in the development of antidotes for the treatment of cocaine overdose.

See also

• BD1031
• LR132