BD1063
From Infogalactic: the planetary knowledge core
Systematic (IUPAC) name | |
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1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine
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Identifiers | |
CAS Number | 150208-28-9 |
ChemSpider | 499765 |
Chemical data | |
Formula | C13H18Cl2N2 |
Molecular mass | 273.20 g/mol |
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BD1063 or 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 ± 1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor.[1]
Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine.[1]
In other animal studies, BD1063 blocks the effects of MDMA,[2] and reduces alcohol intake in rodent models of alcoholism.[3]
See also
References
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- Chloroarenes
- Piperazines