Bacterial neuraminidase
From Infogalactic: the planetary knowledge core
| BNR/Asp-box repeat | |||||||||
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| File:PDB 1euu EBI.jpg
Structure of a bacterial sialidase.[1]
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| Identifiers | |||||||||
| Symbol | BNR | ||||||||
| Pfam | PF02012 | ||||||||
| Pfam clan | CL0434 | ||||||||
| InterPro | IPR002860 | ||||||||
| SCOP | 1euu | ||||||||
| SUPERFAMILY | 1euu | ||||||||
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Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its function is to cleave a sialic acid residue off ganglioside-GM1 (a modulator of cell surface and receptor activity) turning it into asialo-GM1 to which type 4 pilli (attachment factors) bind preferentially.
References
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