Bendroflumethiazide

Bendroflumethiazide

File:Bendroflumethiazide.svg
File:Bendroflumethiazide-3D-vdW.png
Systematic (IUPAC) name
3-Benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com	Consumer Drug Information
Pregnancy category	Risk neonatal thrombocytopenia in 3rd trimester
Legal status	UK: POM (Prescription only)
Routes of administration	Oral
Pharmacokinetic data
Bioavailability	100%
Protein binding	96%
Metabolism	extensive
Biological half-life	3-4 hours
Identifiers
CAS Number	73-48-3 Y
ATC code	C03AA01 (WHO)
PubChem	CID: 2315
IUPHAR/BPS	7122
DrugBank	DB00436 Y
ChemSpider	2225 Y
UNII	5Q52X6ICJI Y
KEGG	D00650 Y
ChEBI	CHEBI:3013 Y
ChEMBL	CHEMBL1684 Y
Chemical data
Formula	C15H14F3N3O4S2
Molecular mass	421.415 g/mol
SMILES FC(F)(F)c3c(cc1c(NC(NS1(=O)=O)Cc2ccccc2)c3)S(=O)(=O)N
InChI InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23) Y Key:HDWIHXWEUNVBIY-UHFFFAOYSA-N Y
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Bendroflumethiazide (INN), formerly bendrofluazide (BAN), trade name Aprinox, is a thiazide diuretic used to treat hypertension.

Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Adverse effects

Common adverse effects:

• postural hypotension
• hyponatraemia, hypokalaemia, hypercalcaemia
• gout
• impaired glucose tolerance
• impotence
• fatigue
• pulmonary oedema
• pneumonitis

Rare adverse effects:

• thrombocytopenia
• agranulocytosis
• photosensitivity rash
• pancreatitis
• renal insufficiency

Alcohol

Bendroflumethiazide is known to have an adverse interaction with alcohol. It is advised that those using this diuretic should abstain from alcohol consumption during use, as it is possible to experience a sudden drop in blood pressure, especially if standing up.

Other considerations

Bendroflumethiazide should not be used by pregnant women, or women who have just given birth. Due to the nature of the medication, it is possible for it to pass into the breast milk and consequently to the child. It is also known that bendroflumethiazide suppresses the production of breast milk. Pregnant or lactating women with hypertension may need to discuss with their prescriber as to which alternative treatment may be more suitable. Bendroflumethiazide may also impair the user's motor skills, therefore it is important to be aware of its effects and to take caution when operating machinery of driving.