Bombesin
From Infogalactic: the planetary knowledge core
400px | |
Names | |
---|---|
Other names
Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
|
|
Identifiers | |
31362-50-2 ![]() |
|
ChEMBL | ChEMBL437027 ![]() |
ChemSpider | 26286924 ![]() |
616 | |
Jmol 3D model | Interactive image |
PubChem | 16133891 |
|
|
|
|
Properties | |
C71H110N24O18S | |
Molar mass | 1619.85 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
|
![]() ![]() ![]() |
|
Infobox references | |
Bombesin is a 14-amino acid peptide[1] originally isolated from the skin of the European fire-bellied toad (Bombina bombina).[2] It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3.[3] It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.[4]
Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, pancreatic cancer, and neuroblastoma.[5]
See also
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ "Isolation and Structure of Bombesin and Alytesin, two Analogous Active Peptides from the Skin of the European Amphibians Bombina and Alytes" by A. ANASTASI, V. ERSPAMER and M. BuccI http://download.springer.com/static/pdf/258/art%253A10.1007%252FBF02145873.pdf?auth66=1384653010_1b792225201410812f5c123e46ce10a5&ext=.pdf
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
Categories:
- Pages with broken file links
- Articles without KEGG source
- Articles without UNII source
- Articles with changed InChI identifier
- Pages using collapsible list with both background and text-align in titlestyle
- Chemical articles using a fixed chemical formula
- Articles that show a Medicine navs template
- Neuropeptides
- Pyrrolidones
- Indoles
- Imidazoles