Budipine

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Budipine
Budipine.svg
Systematic (IUPAC) name
1-tert-butyl-4,4-diphenylpiperidine[1]
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
CAS Number 57982-78-2 YesY
ATC code N04BX03 (WHO)
PubChem CID: 68778
ChemSpider 62021 YesY
UNII L9026OPI2Z YesY
KEGG D07306 YesY
ChEMBL CHEMBL334491 YesY
Chemical data
Formula C21H27N
Molecular mass 293.446 g/mol
  • c1(ccccc1)C3(c2ccccc2)CCN(C(C)(C)C)CC3
  • InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3 YesY
  • Key:QIHLUZAFSSMXHQ-UHFFFAOYSA-N YesY
  (verify)

Budipine (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease.[2][3][1]

While its exact mechanism of action is not well characterized,[2] it is believed to be an NMDA receptor antagonist,[4][5] but also promoting the synthesis of dopamine.[6]

Because it provides additional benefits relative to existing treatments, it probably does not precisely mimic the mechanism of an existing known treatment.[6][7]

See also

References

  1. Martndale: The Complete Drug Reference, 35th Ed.
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  4. J. Kornhuber, B. Herr, J. Thome, P. Riederer. "The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue". J.Neural Transm.Suppl. 46:127-133, 1995. PMID 8821048
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