CALCRL
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein.[1]
Contents
Function
The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.
The association of CALCRL with different RAMP proteins produces different receptors:[2][3]
- with RAMP1: produces a CGRP receptor
- with RAMP2: produces an adrenomedullin (AM) receptor, designated AM1[4]
- with RAMP3: produces a dual CGRP/AM receptor designated AM2
These receptors are linked to the G protein Gs,[5] which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).
Structure
CALCRL associated with RAMP 1 produces the CGRP receptor which is a trans-membrane protein receptor that is made up of four chains. Two of the four chains contain unique sequences. It is a heterodimer protein composed of two polypeptide chains differing in composition of their amino acid residues. The sequence reveals multiple hydrophobic and hydrophilic regions throughout the four chains in the protein.[6]
Clinical significance
These G-protein coupled receptor (GPCRs) proteins play an important role in pharmaceutical targets. Many drugs used today alter the GPCR signaling pathways,[6] notably calcitonin gene-related peptide receptor antagonists that are under investigation for the treatment of migraine.
References
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- ↑ 6.0 6.1 PDB: 3N7S; Lua error in package.lua at line 80: module 'strict' not found.
Further reading
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External links
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- calcitonin receptor-like receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
- CALCRL human gene location in the UCSC Genome Browser.
- CALCRL human gene details in the UCSC Genome Browser.
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