CCL17

Chemokine (C-C motif) ligand 17
250px PDB rendering based on 1nr2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1NR2, 1NR4
Identifiers
Symbols	CCL17 ; A-152E5.3; ABCD-2; SCYA17; TARC
External IDs	OMIM: 601520 MGI: 1329039 HomoloGene: 2246 GeneCards: CCL17 Gene
Gene ontology Molecular function • receptor binding • chemokine activity • CCR chemokine receptor binding Cellular component • extracellular region • extracellular space Biological process • monocyte chemotaxis • chemotaxis • inflammatory response • G-protein coupled receptor signaling pathway • cell-cell signaling • multicellular organismal development • neutrophil chemotaxis • positive regulation of GTPase activity • negative regulation of myoblast differentiation • lymphocyte chemotaxis • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CCL17 207900 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6361	20295
Ensembl	ENSG00000102970	ENSMUSG00000031780
UniProt	Q92583	Q9R043
RefSeq (mRNA)	NM_002987	NM_011332
RefSeq (protein)	NP_002978	NP_035462
Location (UCSC)	Chr 16: 57.4 – 57.42 Mb	Chr 8: 94.81 – 94.81 Mb
PubMed search	[1]	[2]

Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine family is also known as thymus and activation regulated chemokine (TARC). CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1.